We collect, record, and analyze key socio-economic indicators related to social inclusion, employment, and quality of life in the South Aegean. We highlight best practices that contribute to social integration, cohesion, and inclusion. Through digital applications, surveys, awareness-raising activities, and the participation of all municipalities in the Cyclades and the Dodecanese, the Social Inclusion Observatory promotes reliable information and provides proposals and tools to improve the quality of life across the islands of the South Aegean Region.